You know that feeling where you need to get something done, yet can’t find the focus or motivation to do it?
The following stack is designed to clear your head, give you the necessary mental power and crystal clear focus you need in order to get that task done.
The stack contains supplements that will lower your serotonin and boost your dopamine, noradrenaline as well as acetylcholine which will enable you to put in the effort, without even noticing the time go by.
Serotonin (bad): lowers motivation and focus, induces mind grogginess (brain fog), anxiety, lack of ambition, frustration, hopelessness, learned helplessness etc…
Dopamine (good): increases motivation and focus, happiness, ambition, creativity, problem-solving, optimism, enjoyment, etc…
Noradrenaline (good): Increases focus, enhances attention span, working memory, cognitive flexibility, antagonistic to ADD and ADHD, etc…
Acetylcholine (good): enhances neurological brain function, enhances memory formation, increases dopamine, etc…
Here follow 6 supplements that can be used together when focus is required, be it when writing a book, cramming for an exam, or whatever it may be, this stack will help you get it done with a laser sharp and focused mind.
Caffeine, the most famous nootropic, decreases serotonin and is an agonist to dopamine receptors. Caffeine also increases acetylcholine release by antagonism of local adenosine receptors and enhanced psychostimulation. I advise to start with 200mg and if you’re already used to caffeine, up the dose to 400mg.
- Caffeine – 200mg per serving, 100 servings
2) BCAA + phenylalanine + B6
Serotonin and dopamine are synthesized from tryptophan and tyrosine respectively. BCAA competes with both precursors for uptake in the brain and by just taking BCAA will reduce both serotonin and dopamine. That’s why we combine it with phenylalanine, which is also a dopamine agonist.
Phenylalanine is better than tyrosine at increasing dopamine and phenylalanine also inhibits serotonin synthesis, via inhibiting the enzyme tryptophan hydroxylase 2 (TPH2).
Vitamin B6 is a cofactor in catecholamine synthesis, and B6 supplementation has been shown to boost catecholamines, such as dopamine in the brain. Start with 5g BCAA + 2g phenylalanine and 10mg pyridoxal 5 phosphate (P5P), which is the active form of vitamin B6.
- BCAA – 16oz, unflavoured
- Phenylalanine – 500mg per cap, 120 caps
- Vitamin B6 (P5P) – 50mg per cap, 60 caps
Creatine is very effective at restoring brain bioenergetics at the cellular level. Creatine supplementation reduces plasma free-tryptophan and the free-tryptophan:tyrosine ratio, thus increasing dopamine:serotonin ratio. Creatine also has an antidepressant-like effect which is mediated by an activation of dopamine D₁ and D₂ receptors as well as adenosine receptors. It is best to use 5g.
- Creatine – 16oz
Taurine is a serotonin antagonist, it increases dopamine and noradrenaline synthesis and is also a GABA agonist. All in all, taurine will calm your mind, as it’s anti-anxiety and a strong GABA agonist, and is well known to enhance mental focus. Use 500-1000mg.
- L-Taurine – 500mg per cap, 100 caps
Forskolin is able to stimulate dopamine formation from tyrosine via tyrosine hydroxylase and also via potassium-evoked stimulation. Forskolin also increases dopamine receptors as well as their sensitivity. Start with 400mg.
- Forskolin (40% extract) – 400mg per serving, 60 servings
Magnolia potently lowers cortisol, is antagonistic to serotonin and increases dopamine and acetylcholine release in the brain. Start with 400mg.
- Magnolia – 400mg per serving, 60 servings
7) Epicatechin gallate (EGCG)
This one seals the deal. EGCG exerts a modest inhibitory effect on L-DOPA methylation (breakdown via COMT) plus a strong neuroprotective effect against oxidative damage and degeneration. EGCG is one of the strongest natural COMT inhibitors. (1)
- EGCG – 400mg per serving, 180 servings
8) Bonus: alpha GCP (alpha-glycerophosphocholine)
In case you’re not a big egg or organ meat eater, you can include some choline.
Alpha GCP increases dopamine and improves fluidity of the brain neuronal membrane. Start with 300mg.
- Alpha-GCP – 300mg pharmaceutical grade CDP-choline per cap, 60 caps