BPC-157: a fundamental health stabilizing compound

BPC (Body protective compound)-157 is a very interesting peptide with fantastic benefits, far beyond just joint healing.

BPC is a protein that is naturally found in stomach acid. BPC 157 is a 15 amino acid long fragment of this protein and it’s synthetically produced. BPC 157 is great because it’s native and stable in human gastric juice compared to other supplements/peptides.

The reason why I find BPC-157 so fascinating is because BPC is considered a novel mediator of Selye’s stress coping response to reestablish homeostasis.

Dr Ray Peat always talks about the benefits of stabilizing compounds, such as pregnenolone, progesterone, CO2, coffee, thyroid, etc., and BPC-157 appears to is one of them. Except IMO, BPC-157 is a lot stronger than the others.

The reason why I say this is because BPC-157 helps to cope with stress and prevents stress and toxin-induced damage and speeds up the regeneration and recovery of injuries that are struggling to recover.

More on this in just a bit.

Furthermore, because BPC is naturally found in the body, it has very few to no side effects. There are no human studies with it yet, but there are plenty of animal studies with it, none of which report any notable side effects. Lastly, there are so many physicians that use BPC-157 on their patients (either on its own or in conjunction with other peptides/substances) and people that use it on themselves, that there are now enough anecdotal evidence to show that it’s highly effective and with almost no side effects (depending on the source ofc).

BPC-157 on Neurotransmitters

BPC-157 stabilizing effects shine brightly when it comes to neurotransmitters. BPC-157 doesn’t simply boost this and inhibit that, but it regulates neurotransmitter levels and functions. It stabilizes them; enabling them to work normally.

BPC-157 has beneficial effects within the specifically (over)stimulated or damaged (since it’s neuroprotective and neuroregenerative) dopaminergic, serotoninergic, GABAergic and opioid systems.

Nevertheless, BPC 157 is said to have no direct effects on behavior.

Serotonin

A quick intro on serotonin.

  • Serotonin is synthesized via tryptophan hydroxylase 1 (TPH) in the brain and TPH2 in the body from the amino acid tryptophan. 90-95% of total body serotonin is produced through TPH2 in the gut lining.
  • Serotonin acts on a variety of its receptors (5-HT1A to 5-HT7) with different effects.
  • Serotonin is predominantly broken down by monoamine oxidase-A (MAO-A).

Back to BPC-157.

A single dose of BPC-157 significantly reduced the regional rate of serotonin synthesis in the dorsal thalamus, hypothalamus, hippocampus, and lateral geniculate body, while in the substantia nigra reticulate and medial anterior olfactory nucleus the synthesis was enhanced (although expected, no change in the synthesis rate was observed in the raphe nuclei) (R).

However, following a 7 day treatment, there was a significant decrease of serotonin synthesis in the dorsal raphe nucleus (the area of the brain where serotonin is the most abundant neurotransmitter), and an enhancement in the superior olive, substantia nigra, lateral caudate, and accumbens nucleus (R).

BPC-157 has potent, immediate and long term, anti-depressant effects, compared to other anti-depressants, such as SSRIs.

In chronic unpredictable stress procedure, particular aggravation of experimental conditions markedly affected the conventional antidepressant activity, whereas BPC 157 effectiveness was continuously present. The effect of daily imipramine (30 mg) medication could be seen only after a more prolonged period, but not after a shorter period (i.e., 4-d protocol). In these conditions, no delay in the effectiveness was noted in BPC 157 medication and a reduction of the immobility of chronically stressed rats was noted after both 4 and 6 d of BPC 157 (10 microg, 10 ng) medication.

Reference

Furthermore, BPC-157 reduces fear and promotes social resilience, exploration, etc, which is a sign of reduced stress and better functioning/balanced neurotransmittion (R).

But actually, BPC-157 counteracts the negative effects of SSRIs.

BPC 157 diminished or even abolished mild disturbances in rats underwent pargyline (MAO-A-inhibitor) (mild hypothermia, feeble hind limbs abduction) and even severe serotonin syndrome in rats that received both pargyline and L-tryptophan (serotonin precursor).

Reference

It could be due to the stabilizing effects of BPC-157 which prevent the excess synthesis/accumulation/receptor activation of serotonin (BPC-157 reverses the effects of MAO-A inhibitors) and also because of its specific counteraction of 5-HT2A receptors (R, R).

BPC-157 blocks the high serotonin symptoms such as hyperthermia and wet dog shake (by 5-HT2A antagonism) and mild hypothermia, feeble hind limbs abduction (possibly through 5-HT1A antagonist) (R).

Dopamine

BPC-157 also has stabilizing effects on the dopaminergic system.

BPC-157 has been shown to:

  • Counteract the consequences of dopamine-related nigrostriatal neuronal damage, dopamine vesicle depletion, dopamine receptors blockade, and the consequences of reduced dopaminergic activity (R).
  • Attenuate the heightened startle response from amphetamine (R).
  • Counteract the effects of dopamine-system dysfunction and over-function.

GABA

BPC-157 acts by favoring the homeostasis of the GABAergic system, as well as by upregulating the GABAergic neurotransmission.

When BPC-157 is combining with diazepam (aka Valium; a positive allosteric modulator of the GABA type A receptors), it prevented diazepam tolerance development, which is most likely through maintaining the natural homeostasis of the GABA receptor complex (R). This effect also protected/prevented diazepam withdrawal (R).

Dysfunctional neurotransmitter conditions

Lastly, BPC-157 has been shown to be effective for many neurotransmitter dysregulation conditions, such as (R):

  • Akinesia
  • Catalepsy
  • Somatosensory disorientation
  • Tremor
  • Seizures
  • Stereotypies (both acute and chronic)
  • Hypothermia, hyperthermia, climbing and helpless behaviour and serotonin syndrome
  • Acute and chronic alcohol intoxication
  • Morphine–induced analgesia
  • Diazepam tolerance and dependence
  • Muscle weakness and function failure
  • Amphetamine supersensitivity
  • Morphine, naloxone, picrotoxin and isoniazid convulsions
  • Cuprizone effects, a neurotoxin mimicking multiple sclerosis brain lesions and presentation

BPC-157 and Regeneration

Gut

BPC is naturally found in gastric juice and promotes the healing of the intestine. Some people have reduced acid secretion and as a result, reduced BPC levels, or simply, reduced BPC secretion with gastric juice, and they suffer from more gastrointestinal disorders.

BPC 157 is involved in the maintenance of GI mucosa integrity, with no toxic effect. BPC 157 therapy has been successful in healing the GI tract (including healing the intestinal anastomosis and fistulas and improves adaptation of the intestinal wall layers after massive resection) and is well known for its anti-ulcer effects (R).

It’s not only protective in the gut, but also helps to recover lower esophageal sphincter and pyloric sphincters function (R).

Last, but not least, BPC-157 counteracts many lesions that may appear, for instance, with NSAIDs-overdose in the GI tract (R).

Organs

BPC-157 isn’t just effective in the gut, but has regenerative properties in the rest of the body as well. It’s a known organ-protective compound. It’s very effective at preventing and regenerating wounds and lesions in various organs, such as the liver, pancreas, brain, kidney, cornea, etc (R).

Joints & Bone

The most common use for BPC-157 is to speed up recovery after an injury, especially in athletes.

If the injury is fresh or is stubborn and stays sore for months, then BPC-157 can be very effective at speeding up recovery.

BPC-157 has been shown to aid in the regeneration of (R):

  • Deep skin burns
  • Transected/injured muscle
  • Tendon & ligament
  • Bone (pseudoarthrosis, periodontitis)

In this animal study, the scientists crushed the gastrocnemius muscle complex of rats to measure the regeneration on its own, with a cortisol derivative (6alpha-methylprednisolone), with BPC-157 and with 6alpha-methylprednisolone + BPC-157. The results were as follows.

Without therapy, crushed gastrocnemius muscle complex controls showed limited improvement. 6alpha-methylprednisolone markedly aggravated healing. In contrast, BPC 157 induced faster muscle healing and full function restoration and improved muscle healing despite systemic corticosteroid treatment when given intraperitoneally or locally (cream) and demonstrated functionally, macroscopically, and histologically at all investigated intervals.

Reference

And this is just one of the many studies showing the healing/regenerative properties of BPC-157.

BPC-157 speeds up recovery by:

  • Increasing growth hormone receptors in tendon fibroblasts, which may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon (R).
  • Enhancing blood vessel function
  • Promoting new blood vessel formation through angiogenesis, upregulating VEGF, EGF, etc.
    • Hearing angiogenesis might raise the neck hairs of a few people, as it did for me, because angiogenesis is highly upregulated in tumors and cancer, which means that BPC-157 might be dangerous for cancer patients. However, this study found that BPC-157 actually counteracted the tumor-promoting effect of VEGF (R).
  • Inhibiting inflammatory mediators, such as TNFa, IL-6, etc.
  • Lowering catabolic proteins, such as FoxO3a
  • Increasing anabolic markers, such as Akt/mTOR

Blood vessels, blood flow and tissue oxygenation

BPC-157 is highly beneficial for the circulatory system. As already mentioned, BPC can promote the formation of new blood vessels and can also increase vessel recruitment that circumvents vessel occlusion and the development of additional shunting and rapid bypass loops to rapidly reestablish the integrity of blood flow (ischemic/reperfusion colitis, duodenal lesions, cecal perforation, and inferior vena caval occlusion) (R).

Furthermore, BPC-157 has a stabilizing effect on the circulatory system by counteracting complications of either nitric oxide synthase inhibitor (i.e., various lesions aggravation, hypertension) as well as NOS promotors (i.e., hypotension, prolonged bleeding, thrombocytopenia).

Lastly, BPC-157 prevents NSAID complications, such as aspirin-induced prolonged bleeding and thrombocytopenia (R).

Muscle wasting

BPC-157 might not be anabolic in the sense that it will help you build tons of muscle, but it can help to prevent excess catabolism, due to dysfunctional metabolism.

BPC-157 has been found to counteract “tumor cachexia, muscle wasting, and increases in pro-inflammatory/procachectic cytokines, such as interleukin-6 and tumor necrosis factor-α, and significantly corrects deranged muscle proliferation and myogenesis through changes in the expression of FoxO3a, p-AKT, p-mTOR, and p-GSK-3β (mitigating cancer cachexia)” (R). Very awesome if you ask me.

Dosing

Since there are no human studies yet, there is no well-established dose for certain conditions. However, people use anywhere from small doses, up to big doses. The standard dosing used for muscle/ligament/tendon recovery is usually around 250-300mcg spot specific injections twice daily for about 10+ days.

Longer term doses can be used. It all depends on how well it works for you and how much recovery is needed.

BPC-157 can also be taken intranasally, sublingually, or orally.

If you want to fix gut issues (ulcers/leaky gut, etc.) then oral is the way to go. If you have overall inflammation and degeneration due to chronic long term gut inflammation and leaky gut, then oral dosing might be the best, because it will address the root cause. If you want to learn more about how to fix the gut, digestion and lower chronic inflammation, then check out the Alpha Energy Nutrition Course.

If you want to use it as an anti-depressant and reduce brain inflammation, intra-nasal/sublingual dosing might be the way to go.

If you want to heal an injury, then direct (subcutaneous or intramuscular) injections at/near the injury would most likely yield the best effects.

Conclusion

BPC-157 is very (dare I say extremely) safe and has a very high safety (no reported toxicity (LD1 could be not achieved)) profile (R).

A small percentage of people might react negatively to BPC-157 and it might be because of a bad quality product they bought or because they have an overactive immune system (although this also only happens to a small percentage of people with an immune condition and in some cases it might be beneficial for some people with immune conditions).

In the case of a compromised immune system, then taking Thymosin alpha 1 and/or Thymosin Beta-4, with or before BPC-157 should help to prevent the body from reacting to BPC-157.

I’ve only been using this for about 3 days now and so far the benefits that I’ve been experiencing include: tighter skin (collagen re-modulization), higher stress resilience, better mood, better energy for longer and better muscle repair.

Anya Amato

As a side note, we’ll update this testimony after finishing the vial; and if we decide to get more or not.

3 Replies to “BPC-157: a fundamental health stabilizing compound”

  1. Hi Hans,

    I used 1 capsule (250mcg) of BPC-157 arginine salt orally around two months ago. Since then I have had severely blunted responses to things like caffeine, phenylpiracetam and yohimbine. This is maybe expected because of the effects on DA but I had used nearly 10mg of BPC-157 acetate subcutaneously 10 months prior for gastritis and didn’t notice nearly the same powerful neurological effects.

    I took the capsule at 5 PM and had heart palpitation/tachycardia, stomach upset and insomnia when trying to go to bed at 11 PM that evening. The BPC-157 arginine salt version is purported to be far more stable in gastric acid so I assume that’s why the negative side effects were so much more pronounced. I sent a couple of the capsules in for third party analysis and it is indeed legitimate BPC-157.

    My question is are these neurological side effects (blunted DA) permanent/epigenetic? I really hope they aren’t because it has certainly sapped some of the joy out of my life. If I could do it over again I would not have purchased the arginine salt kind.

    1. I have not come accross any research to suggest that it has epigenetic effects, however, some of its benefits are tend to remain over a long period of time.
      It’s strange that you experienced heart palpitation/tachycardia, since as far as I know it doesn’t affect the synthesis and release of dopamine or noradrenaline, but only signalling. And even then it only stabilizes neurotransmission.
      Perhaps there was other ingredients in the caps as well besides just BPC-157 that weren’t listed? Since it was in cap form, it most likely also had other excipients in it.

      1. Perhaps, the palpitation/tachycardia could have been because of angiogenesis. Stabilizing or in my case severely blunting dopaminergics seems about right. Relieved to hear you weren’t able to find anything that indicates epigenetic effects, means it should get better with time. Thank you

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