Are androgen receptors increased or inhibited by zinc?

One study in 2018 showed that zinc antagonizes the androgen receptor in vitro in prostate cancer cells. But that does not mean zinc will antagonize the AR in a non-cancerous cell or anywhere else in the body.

A more recent 2020 study found that zinc supplementation significantly increased testosterone and androgen receptors in rat prostate without cancer (R).

Furthermore, zinc is a crucial part of the androgen receptor. Low zinc can lead to low AR. This could be why zinc supplementation increased androgen receptors as shown in the study above.

Lastly, low zinc leads to low testosterone, high estrogen, very low testosterone to estrogen ratio, low DHT, high 3alpha-diol (weak DHT metabolite) and an awful DHT to 3alpha-diol ratio.

All in all, low zinc reduces androgenic signaling and increases anti-manly hormones, such as estrogen, serotonin and prolactin.

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3 Replies to “Are androgen receptors increased or inhibited by zinc?”

  1. Some claim supplementing high dose of zinc is anti androgenic? Know some rare cases who got PFS like symptoms from it.

    This true? And when supplementing zinc, what dose do you suggest? Thanks

    1. I think it’s more likely because it caused imbalances with other minerals such as copper.

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