40 best ways to increase DHT (2020 update)

DHT, the apex androgen for all men. Testosterone is only thought to be a precursor hormone in the body for the synthesis of DHT, which is the most potent alpha hormone. It’s like cholesterol that’s the precursor to pregnenolone and testosterone. Many of the beneficial effect of testosterone is actually through DHT, and blocking the…

Does Niacinamide contribute to diabetes and insulin resistance?

Vitamin B3 comes in a few forms, with niacin (nicotinic acid (NA)), niacinamide (NAM), nicotinamide riboside (NR) and inositol hexanicotinate being the most famous. As you can see from the picture, vitamin B3 can come in three forms from the diet, namely NA, NAM and NR, whereas an endogenous pathway can also synthesize NAM from…

Excessive fat oxidation (β-oxidation) drives diabetes

An association between intracellular fat accumulation and insulin resistance has been found. But an association is not a cause… The hypothesis was that β-oxidation is too slow and as a result, fats start to accumulate in the cells and this causes insulin resistance, thus the inability to transport glucose into the cell and reduce glucose…

Uncoupling: Secret to Fat loss and Health

Uncoupling protein, aka thermogenin, are proteins found in the inner mitochondrial membrane of the cell. Protons generated in the Kreb cycle leave the mitochondria via the electron transport chain, and then re-enter the mitochondria via the ATPase enzyme for the synthesis of ATP. This is called coupled respiration. With uncoupled respiration, protons re-enter the mitochondria…

60 Best ways to lower Serotonin (2020 update)

Serotonin has always been thought (or is still being though) of as the happy hormone and that by increasing it, it has an anti-depressant effect, right? What if I told you that’s not true at all. SSRI drugs are the most commonly prescribed drug for depression, anxiety and other mental disorders and more than 90%…

7 amazing benefits of Niacinamide. #4 is boosting brain capacity

There are various forms of niacin out there, a few are nicotinic acid (NA), nicotinamide/niacinamide (NAM), nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). Nicotinic acid has a few side effects, such as flushing, nausea, fainting and can even cause insulin resistance and liver toxicity and exacerbate peptic ulcer disease, which NAM doesn’t have. (1, 2) B3…